The laboratory mice have traditionally been used as a model for various diseases, which suggests that the mechanisms of diseases on physiological and genetic level are the same in humans and vertebrates. The scientists decided to check this paradigm, wrote journal PNAS.
They studied which genes are active in human diseases with an inflammatory nature (trauma, burns, sepsis) and compared them with the genetic profile of a mouse model of inflammation. For the comparison are used DNA analysis of 421 patients.
It was found that 77-93% of the mouse and human genes for inflammatory diseases change the profile of their reaction in a similar manner. This demonstrates that the mouse model of inflammation was adequate.